What is Pulrial? Who is it suitable for, and who is it not suitable for, regarding skin firmness and hydration

Pulrial is a treatment in which a component called polynucleotide (PN) is injected into the skin to gradually improve firmness, hydration, and skin texture.[1][2]In tests around the eye area, there was no difference in visible improvement between PN and hyaluronic acid, but PN showed better results in hydration and skin texture measurements.[3]On the other hand, its ability to add volume is limited, and it is not suitable for people who want to fill deep hollows.[4].

How is PN different from hyaluronic acid?

The biggest difference is whether it fills gaps or improves the foundation of the skin. PN is a fragment of DNA extracted from fish such as salmon, and is thought to be involved in the reorganization of collagen and other components within the skin.[1].

While hyaluronic acid fillers immediately fill hollows visibly, PN tends to improve skin quality over time.[4]There is also a similarly named component called PDRN, but it differs in the length of DNA fragments and how it works.[1].

What concerns is it suitable for?

It is suitable for people concerned with skin firmness, hydration, fine lines, and rough skin texture. In a trial of 27 people in which PN and hyaluronic acid were each injected on opposite sides around the eyes, the improvement rate for skin elasticity, hydration, skin texture, and pores was higher on the PN side.[3].

Conversely, if the main concern is deep hollows under the eyes or insufficient volume in the cheeks, PN alone tends to feel insufficient.[4]The choice of treatment depends on which concern is central.

What is the guideline for frequency and interval?

In research, a method of repeating injections at intervals over multiple sessions is commonly used. In the 27-person trial mentioned earlier, injections were administered every 2 weeks for 3 sessions.[3].

However, the depth and frequency of injection vary from study to study, and there is no established standard yet.[4]There is also a consensus document compiled by 8 experts, but this too is a guideline based on research and experience.[5].

What about side effects and downtime?

The most common are redness and swelling at the injection site, which is usually temporary.[6]In reports summarizing PN research, side effects were mainly mild and short-lived.[2].

With injectable agents that promote skin regeneration, nodules or granulomas (small lumps formed by the body's reaction) can rarely occur, and experts caution that procedures for managing these should be established in advance.[6]If swelling persists or you notice nodules after injection, consult early.

How much is known from research?

Research on PN is increasing, but small-scale studies remain the focus. In reports summarizing research, there is variation in research quality, and results need to be received with caution.[7][2].

Additionally, no research was found using the product name Pulrial. This article explains based on research of other products using the same ingredient.

What should you confirm in a consultation before treatment?

You should confirm whether your concern is a skin quality issue or a volume deficiency. If hollows are noticeable, comparison or combination with hyaluronic acid and similar products may be considered.

Also ask about the injection site, frequency and interval, and how to spend time until redness and swelling subside. Since skin condition varies from person to person, it is most reliable to have it examined and consult with your doctor to decide.