PluRial
A "skin-building agent" that strengthens skin itself by supplementing the skin's inherent self-repair ability
Recommended for
- I want to improve dry skin
- I want to improve skin redness and uneven tone
- I am concerned about deep facial wrinkles and fine lines
- I want to reduce neck wrinkles
- I want to enhance skin firmness
- Those concerned about allergies
Skin becomes strong and beautiful from within
"PluRial Densify" is an innovative biostimulator (biological stimulation) agent focused on skin regeneration, developed by MD Skin Solutions in Luxembourg and has obtained "CE approval." It is a filler with a proven track record of use in over 20 countries. Primarily, it is a new injectable agent that approaches the skin's unique self-repair ability.
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【Products handled at our clinic】
●PluRial Densify
●PluRial BioSculpture
Features
"Biostimulator agents" receiving attention in recent years
■Bio (biological) + Stimulation (stimulus)■Works on declining skin function and cells themselves■Main ingredient uses polynucleotides (PN), whose safety to the human body is recognized Most previous injectable agents aimed to supplement decreased skin moisture and collagen, but this series uses polynucleotides (PN) derived from salmon as the main ingredient and promotes skin repair and regeneration through biostimulation (biological stimulation) that activates fibroblasts. In this process, it addresses wrinkles and Sagging (skin laxity) while delivering beautiful skin effects, and simultaneously improves dermatitis and wounds, resulting in stronger skin.
Main ingredient "Polynucleotide (PN)"
■Component extracted from the DNA of salmon or trout■High compatibility with skin■Promotes tissue repair, anti-inflammatory action, antioxidant action, angiogenesis■Reduces inflammatory cytokines that cause aging symptoms■Increases various growth factors■Comprehensive beautiful skin effects including wrinkles and wound healing When polynucleotide (PN) is injected into the body, cells mistake it as damage, activating tissue regeneration and skin repair. Anti-inflammatory action is exhibited and cytokines are released. Simultaneously, collagen production is promoted, leading to beautiful skin.
High-safety formula
"PluRial Densify" complies with EU regulations and is a formula that has obtained "CE approval," which guarantees safety in Europe. By increasing polynucleotide purity and completely removing proteins, allergy risk is significantly reduced, resulting in a high-safety formula design. What is CE? CE refers to the organization equivalent to Japan's Ministry of Health, Labour and Welfare. By meeting the safety performance standards set by EU law, products can display the CE mark.
DENSIFY Densify
■Unique combination of PN with non-crosslinked hyaluronic acid and mannitol■Increased PN purity and complete removal of proteins reduce allergy risk■Possible to improve overall skin condition■Effective for improving firmness and radiance A new formula that combines polynucleotide (PN) with non-crosslinked hyaluronic acid and mannitol in a unique blend. The synergistic effect of three types of skincare ingredients results in higher stimulation effects on cells and tissues compared to treating each ingredient individually. With just one injection, it can approach skin efficiently, and the effects last longer. It is suitable for injection into the entire face, neck, décolletage, and other areas, leading to refined skin by addressing skin troubles from dryness and sebum, and improving lack of firmness and volume.
BIOSCULPTURE BioSculpture
■Three types of hyaluronic acid formulated with special technology■Lasting effects + skin regeneration realized■Addresses deeper wrinkles and Sagging (skin laxity)■Less likely to cause allergic reactions and safe■Low amount of crosslinker allows easy diffusion in the body and less likely to cause nodules Composed of three types of hyaluronic acid: crosslinked hyaluronic acid (high molecular weight and medium molecular weight) and non-crosslinked hyaluronic acid (low molecular weight), and by formulating different types of hyaluronic acid in a unique ratio, both durability and skin regeneration effects are realized. Specialized for those who want to refine their contours, restore facial volume lost with age, and improve skin quality.
Treatment details
- Treatment time
- 10-20 minutes (excluding topical anesthesia 30 minutes additional)
- Treatment interval
- Densify: Every 2–4 weeks for 3 sessions (recommended) BioSculpture: Every 1–2 months for 1–3 sessions (recommended)
- Pain during treatment
- Injection pain present (Surface anesthesia, block anesthesia, or nitrous oxide anesthesia recommended)
- Risks
- Bruising, redness, swelling, puffiness, etc.
- Shower and bathing
- 《Shower》 Possible from the same day (Water rinsing of the treated area possible after 6 hours) 《Bathing》 Possible after 24 hours
- Makeup and skincare
- 《Makeup》 Possible after 24 hours 《Facial cleanser and makeup remover》 Possible after 24 hours (Water rinsing of the treated area possible after 6 hours) 《Toner and moisturizer》 Possible after 6 hours 《Makeup and sunscreen》 Possible after 24 hours
Pricing
■PluRial Densify
| Treatment | Unit | Price (incl. tax) |
|---|---|---|
| Partial injection (2cc) | 1 session 3 sessions |
|
| Full-face injection (4cc) | 1 session 3 sessions |
|
■PluRial BioSculpture
| Treatment | Price (incl. tax) |
|---|---|
| 1 vial (1.1ml) |
|
※ All prices include tax.
FAQ
How long does the effect of Pluural last?
While results vary by individual, the improvement in skin firmness and hydration generally lasts approximately 3–6 months per treatment. By continuing regular maintenance treatments every 3–4 months, biostimulator effects accumulate, allowing for longer-term skin quality improvement. Since the polynucleotide (PN) component activates fibroblasts within the dermis, collagen production is promoted, and with each successive treatment, the skin's intrinsic quality improves.
ZetithAIに続けて聞く →How much downtime is there after treatment?
Mild redness, swelling, and bruising may occur from the injection, but typically subsides within 2–3 days. In most cases, makeup is possible immediately after treatment; however, please avoid strenuous exercise, alcohol, and sauna on the day of treatment. Please also avoid strong stimulation to the injection site for several days. Since there is minimal noticeable downtime, this treatment is accessible even for busy individuals.
ZetithAIに続けて聞く →What is the difference from hyaluronic acid injection (filler)?
Pluural is a biostimulator formulation designed for "skin rejuvenation," fundamentally different from hyaluronic acid fillers. Fillers provide immediate physical volume through injection, but Pluural's primary component, polynucleotide (PN), stimulates fibroblasts at the cellular level to promote your skin's own collagen and elastin production. Rather than immediate volume enhancement, this is an approach close to "skin regenerative medicine" that elevates skin quality and intrinsic skin strength.
ZetithAIに続けて聞く →Who is this treatment suitable for? Are there those who cannot receive it?
This treatment is especially suited for those concerned with dryness, dullness, fine lines, and lack of skin firmness, those worried about allergies and uncertain about hyaluronic acid products, and those wishing to improve wrinkles on the neck and décolletage. Conversely, pregnant or breastfeeding women, those with infection or inflammation at the injection site, and those currently using immunosuppressants may not be eligible. Please feel free to schedule a consultation or inquire via LINE or phone. We will provide detailed explanations during your consultation.
ZetithAIに続けて聞く →Consultations about this treatment are free.
Book / free consult via LINE
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