JUVGEN vs. hyaluronic acid injection: what is the difference for deep wrinkles and acne scars?

JUVGEN is a treatment that alternately introduces small amounts of carbon dioxide gas and hyaluronic acid, aiming to promote changes within the skin rather than add volume like hyaluronic acid injection alone. However, research specifically investigating JUVGEN itself is not currently available, so we must rely on studies of carbon dioxide gas injection and hyaluronic acid injection[1][2]. Whether you have deep wrinkles or acne scar depressions, the comparison changes depending on the concern.

Carbon dioxide gas injection vs. hyaluronic acid injection: what is the difference?

Carbon dioxide gas injection (carboxytherapy) is a method of introducing medical-grade carbon dioxide gas into or beneath the skin at a controlled amount.[2] It has been used for skin rejuvenation, depressed scars, and stretch marks.[1].

Hyaluronic acid injection is recognized in the guidelines of Japan's aesthetic surgery society as effective for facial wrinkles.[3]. The ability to lift depressions immediately is a major difference from carbon dioxide gas injection. JUVGEN is a treatment that alternately introduces these two into the same area.

Which is better suited for acne scar depressions?

For acne scar depressions, there are helpful reports on carbon dioxide gas injection. In a study comparing carbon dioxide gas injection and dermapenning (a treatment that makes small holes in the skin with fine needles) on the left and right sides of 32 people's faces, with 6 treatments each, acne scars of all types improved on both sides.[4].

In another study of 20 people, the side where adhesions beneath the skin were released with carbon dioxide gas in addition to laser showed better results than the laser-only side.[5]. Very good results were seen in 10%, approximately 1 in 10 people.[5].

On the other hand, the guidelines of the Japan Dermatological Association do not recommend injecting hyaluronic acid or similar substances for acne scar depressions.[6]. For acne scars, it is more realistic to compare laser, dermapenning, and other options alongside hyaluronic acid injection.[4].

How should deep wrinkles be considered?

If you want to make deep wrinkles appear shallower right away, hyaluronic acid injection that can lift them immediately is the option to compare.[3]. Carbon dioxide gas injection has been noted to sometimes not produce the expected results.[1].

If you choose JUVGEN, deciding beforehand whether you want immediate changes in shape or gradual improvement in skin quality will make the decision easier. If you seek immediate changes, also compare hyaluronic acid injection.

What are the differences in side effects for each?

Carbon dioxide gas injection commonly causes small bruising at the injection site, which typically resolves in a few days.[4]. Rarely, unintended fat loss or prolonged gas retention beneath the skin has been reported.[1].

Hyaluronic acid injection, while rare, carries reports of serious complications such as skin damage or vision problems if the substance enters blood vessels.[3]. Since JUVGEN contains both components, it is reassuring to receive an explanation about the precautions for both.

What should be examined during consultation?

You should have examined the depth and shape of the depression, and whether wrinkles appear with facial expression or are present at rest. For acne scars, the type of depression that is most prevalent also determines which treatment is suitable.

On that basis, ask your doctor why they recommend JUVGEN and how it differs from hyaluronic acid injection and laser treatments. Which option suits your wrinkles or depressions cannot be determined from an article alone, so confirm this during your consultation.