Who is JUVEDERM VOLIFT suitable for? Considering nasolabial folds, mouth wrinkles, and cheek hollowness

JUVEDERM VOLIFT is most suitable for people with moderate to deep nasolabial folds or wrinkles extending downward from the mouth corners (marionette lines). For significant cheek volume loss or when creating skeletal support, note that other hyaluronic acid products are more frequently studied.

Is it suitable for people with deep nasolabial folds?

Moderate to deep nasolabial folds are the most studied area with JUVEDERM VOLIFT. Nasolabial folds are wrinkles extending from the side of the nose to the mouth corner; they become more prominent with age and may create a tired appearance[1].

In a study of Chinese subjects, JUVEDERM VOLIFT showed comparable efficacy to the hyaluronic acid product it was compared against for moderate to deep nasolabial folds[2]. There are also studies comparing different products on each side of the face.[1].

Can it be used for mouth wrinkles (marionette lines)?

Yes. In a study where up to 2 mL was injected into marionette lines and followed for 12 months, improvement was reported by physician assessment, patient self-assessment, and photographic measurement[3]. Satisfaction remained high throughout that period.[3].

However, this study was conducted at a single facility and was not compared with other products.[3]Data specifically examining marionette lines alone is still limited.[3].

What about people with cheek hollowness or those wanting to create skeletal support?

For significant cheek volume loss, multiple studies focus on other products designed for the midface. Systematic reviews of hyaluronic acids for midface volumization covered several products[4].

For creating skeletal support, expert recommendations have been compiled for VYC-25L, a different product[5]. If your concerns are cheek hollowness or jawline shape, asking about which product is right for you—not limited to JUVEDERM VOLIFT—will make comparison easier.

Worried about injection pain?

JUVEDERM VOLIFT contains a local anesthetic (lidocaine). Prior studies reported less injection pain compared to products without anesthetic.[2].

What risks should you know about?

The most common are swelling and redness at the injection site, which usually resolve naturally. In the marionette line study, injection site reactions were within expected range, localized, and resolved without intervention.[3].

Though rare, serious complications can occur. Japan's Society of Aesthetic Surgeons' guidelines recognize hyaluronic acid injection for wrinkles as effective, while noting reports of skin necrosis (tissue damage and death) and vision loss when the product enters blood vessels, urging caution and assigning a recommendation level of 2 (weak recommendation)[6].

If you experience severe pain, skin color changes, or vision abnormalities after injection, it is important to contact the clinic immediately.

What to confirm before treatment

Three benchmarks help with your decision. First, determine whether your concern is wrinkles like nasolabial folds or marionette lines, or volume loss like cheek hollowness.[2][3][4]Second, see how JUVEDERM VOLIFT has been studied for your area.[3]Third, confirm readiness for vascular complications.[6].

Whether JUVEDERM VOLIFT suits your wrinkles, or whether another product or treatment is better, cannot be decided from this article alone. Have a consultation to examine your wrinkle depth and cheek volume.