Juvederm
A bio-revitalization treatment that injects PDRN (polydeoxyribonucleotide) derived from salmon DNA into the dermis to promote collagen production and improve skin firmness, elasticity, and hydration.
Recommended for
- Those concerned with age-related skin changes such as loss of firmness, elasticity, and hydration
- Those resistant to highly invasive treatments like injections or surgery and seeking procedures with short downtime
- Those wishing to address multiple skin concerns simultaneously such as acne scars, fine lines, and dullness
- Those seeking to promote collagen synthesis from within and elevate skin quality long-term
What is Juvederm
Juvederm is an injection-based skin rejuvenation treatment with PDRN (Polydeoxyribonucleotide) as its primary ingredient. PDRN is a mixture of DNA fragments obtained through high-degree purification and sterilization from salmon (trout/salmon) milt, containing low-molecular-weight nucleic acids with a molecular weight of 50–1,500 kDa. Active proteins and peptides are removed during the purification process, keeping immunological reaction risk low (Colangelo et al., Frontiers in Pharmacology, 2017). Micro-injection into the dermal layer activates fibroblasts and promotes the synthesis of collagen and elastin.
Mechanism of Action of PDRN
The primary mechanism of action of PDRN is stimulation of adenosine A2A receptors. Intracellular signaling via A2A receptors has been shown to promote tissue repair and regeneration while suppressing inflammatory cytokines (Colangelo et al., Frontiers in Pharmacology, 2017). Additionally, multiple basic research studies have reported that activation of A2A receptors enhances the function of fibroblasts and endothelial cells, promoting collagen production and angiogenesis (Visalli et al., Frontiers in Pharmacology, 2016). This yields improvements in firmness, elasticity, skin texture, and hydration.
Treatment Flow
After confirming skin condition and treatment goals during consultation, the treatment area is cleansed and disinfected. Using ultra-fine injection needles or cannulas, the PDRN preparation is micro-injected into the superficial to mid-dermis (aqua facial injection or mesotherapy technique is standard). Treatment duration varies by area and number of injections, but typically 30–45 minutes for the entire face. Local anesthetic cream is used, so discomfort during treatment is minimized, though pain perception varies individually.
Downtime and Recovery Progress
Minor redness, bruising, and swelling may occur immediately after injection. In most cases, redness subsides within several hours to 2 days, and bruising typically resolves within 1–2 weeks. Collagen production progresses over weeks, so noticeable effects generally require several weeks or more after the first or second treatment. Downtime can usually be managed with makeup, and most patients can return to normal activities the day after treatment.
Recommended Treatment Interval and Duration of Results
During the initial introduction phase, 2–3 treatments performed at 2–4 week intervals enhance collagen synthesis effects. Thereafter, maintenance treatments once every 1–3 months are recommended. Since PDRN is gradually metabolized in the body, regular maintenance is essential to sustain results. Individual variation exists depending on skin type, lifestyle, and treatment area; timing should be determined in consultation with your physician.
Features
Tissue Repair Promotion via PDRN (Polydeoxyribonucleotide)
PDRN activates fibroblasts via adenosine A2A receptors and promotes synthesis of collagen and elastin. Basic research has demonstrated that it exerts both anti-inflammatory and tissue repair effects simultaneously (Frontiers in Pharmacology, 2017), yielding improvements in skin firmness and elasticity.
Highly Purified Bio-Material with Low Allergen Risk
PDRN derived from salmon milt undergoes advanced purification and sterilization, with allergenic active proteins and peptides removed. This reduces immunological reaction risk and makes it a material suitable for sensitive skin.
Short Downtime with Minimal Impact on Daily Life
Post-injection redness and swelling are typically mild, allowing most patients to resume normal activities the next day. As a minimally invasive treatment without surgery, it is well-suited for repeated treatments.
Collagen Accumulation Effect Through Repeated Treatments
While a single treatment yields results, 2–3 initial intensive treatments strongly promote collagen synthesis; continued regular maintenance thereafter helps sustain and improve skin quality. Repeated treatments tend to increase fibroblast activity.
Pricing
Juvederm (Shinjuku Clinic)
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FAQ
What skin concerns is Juvederm suitable for?
It is suitable for age-related skin concerns such as dryness, fine lines, loss of firmness, dullness, and uneven skin texture. Since PDRN promotes collagen and elastin synthesis, it is ideal for those seeking fundamental anti-aging care from within. It is also used for improving acne scars and promoting skin regeneration.
ZetithAIに続けて聞く →How much pain is involved in the treatment?
Since anesthetic cream is applied before treatment, most patients report only mild pressure or slight tingling sensation. Pain varies depending on injection site, number of needles, and individual sensitivity, though few experience strong pain. If concerned, please consult with your physician during the consultation.
ZetithAIに続けて聞く →When will I see results, and how long do they last?
Collagen production progresses over weeks, so most patients notice changes in skin firmness and hydration 1–2 months after treatment rather than immediately. Duration of results varies individually but is generally 3–6 months, and results are easier to maintain with regular maintenance treatments.
ZetithAIに続けて聞く →How do I make a reservation?
Reservations are accepted via LINE or phone. First-time patients begin with a complimentary consultation. Your physician will individually advise on skin condition, number of treatments, and treatment intervals, so please feel free to contact us.
ZetithAIに続けて聞く →Consultations about this treatment are free.
Book / free consult via LINE
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