Jalupro (JALUPRO)
Jalupro delivers amino acids and non-crosslinked hyaluronic acid directly into the dermis through "Skin Biorevitalization," promoting collagen production and fundamentally improving skin firmness, hydration, and radiance.
Recommended for
- Suitable for those concerned about reduced firmness and hydration who want to fundamentally elevate skin quality
- Suitable for those seeking natural improvement without the dramatic changes of hyaluronic acid fillers or Botox
- Suitable for those with multiple skin concerns such as dryness, dullness, and prominent pores
- Suitable for those who want to combine with other cosmetic treatments (fillers, lift-ups, etc.) to establish a strong skin foundation
What is Jalupro (JALUPRO)?
Jalupro is an Italian-origin medical injectable formulation containing non-crosslinked (free) hyaluronic acid and an amino acid complex (glycine, L-proline, L-hydroxyproline, L-lysine hydrochloride). By injecting directly into the dermal layer, it activates skin fibroblasts and promotes "Biorevitalization (skin regeneration from within)"—enhancing the body's own collagen and elastin production. Unlike hyaluronic acid fillers that create shape or increase volume, this treatment aims to fundamentally elevate skin quality itself.
Scientific Evidence: Why Is the Combination of Amino Acids and Hyaluronic Acid Effective?
The major amino acid constituents of collagen are glycine, proline, and hydroxyproline; supplying these directly into the dermis accelerates fibroblast collagen synthesis. A study of RRS HA formulation published in Clinical, Cosmetic and Investigational Dermatology (2016) demonstrated that a mixed formulation of hyaluronic acid + amino acids increased human skin fibroblast survival rate by 15% and increased Type I collagen gene expression 9.7-fold and elastin gene expression 14-fold in vitro (doi: 10.2147/CCID.S95108). Furthermore, a 2015 study in the same journal showed that injecting a hyaluronic acid + vitamin/mineral/amino acid complex solution 4 times in 64 women resulted in statistically significant improvements in skin radiance, pigmentation uniformity, and deep skin hydration, and significantly reduced visual scores of UVB-induced erythema (doi: 10.2147/CCID.S77742).
Additionally, a 2024 review in Archives of Plastic Surgery (doi: 10.1055/a-2366-3436) presents current comprehensive evidence that injectable skin boosters containing ingredients such as amino acids and hyaluronic acid are effective for age-related skin dullness, dryness, and loss of elasticity. This evidence aligns with Jalupro's ingredient design and mechanism of action, substantiating its clinical validity.
Treatment Flow
After confirming skin condition and goals through consultation, cleansing and disinfection are performed. Jalupro injection uses a fine needle (approximately 32G), with multiple point injections into the superficial dermal layer of the entire face, neck, décolletage, and other areas of concern. A numbing cream is applied beforehand, so discomfort is minimal. Treatment time takes approximately 15–30 minutes depending on the injection area size.
Recommended Course & Downtime
For the initial course, 3–4 injections at 3–4 week intervals are recommended. Multiple treatments allow collagen production to accumulate cumulatively, making results more stable. For maintenance purposes, maintenance injections every 3–6 months are typical. Downtime is mild, with temporary redness and minor swelling after injection (lasting several hours to 1 day) being the main reactions. Bruising may occur but resolves within several days. Makeup application and daily activities are generally unaffected from the next day onward.
Differences from Other Injectable Treatments
Jalupro differs from hyaluronic acid fillers in that it is not formulated for shape correction or volume filling. Because it contains non-crosslinked (non-gelled) hyaluronic acid, it disperses throughout the dermis without creating shape when injected, specializing in improving hydration environment and providing nutritional support to fibroblasts. Its action also differs from botulinum toxin—it has no effect on muscles and does not change facial expression. Since it targets skin quality improvement and foundation-building, it is also used in combination treatments with fillers and lift-up procedures.
Features
Promotes collagen and elastin production from within the body
Glycine, proline, hydroxyproline, and lysine are amino acids essential for collagen synthesis. Direct supplementation into the dermis activates fibroblasts, with notable upregulation of Type I collagen gene expression reported (Clinical Cosmet Investig Dermatol, 2016).
Simultaneous improvement in deep hydration and barrier function
Non-crosslinked hyaluronic acid disperses within the dermis to form a long-chain hydration network, elevating deep skin hydration levels. A 64-subject clinical trial showed statistically significant improvements in all measures of skin radiance, deep hydration, and pigmentation uniformity (Clin Cosmet Investig Dermatol, 2015).
Natural results with no effect on facial expression
Because volume filling and muscle relaxation are not performed, facial expression and face contours remain unchanged after injection. This treatment is suitable for those who "don't want an obviously treated appearance" or who "want to start with skin quality improvement first."
Short downtime with minimal impact on daily life
Mild redness or swelling may occur from the day of injection through the next day, but typically resolves within several hours to 1 day. Makeup application the next day is generally possible, minimizing impact on work or outings.
Pricing
| Treatment | Price (incl. tax) |
|---|---|
| Super Hydro (1 session) |
|
| Super Hydro 3-Session Course |
|
※ All prices include tax.
FAQ
How does Jalupro differ from hyaluronic acid fillers?
Hyaluronic acid fillers use crosslinked (gelled) hyaluronic acid injected to increase volume and correct wrinkles and contours. In contrast, the non-crosslinked hyaluronic acid in Jalupro is not gelled, so it disperses into the dermis after injection without creating shape. Instead, through synergistic effects with amino acids, it activates fibroblasts to promote collagen production and improves skin quality itself. It "improves skin foundation" rather than "changes shape."
ZetithAIに続けて聞く →How many sessions until I see results?
While individual variation exists, some people notice changes in skin hydration and glow after the first session. For more pronounced improvements, a course of 3–4 injections at 3–4 week intervals is recommended, allowing collagen production to build cumulatively through the course for sustained results. Subsequently, effects can be maintained with maintenance sessions every 3–6 months.
ZetithAIに続けて聞く →Are there precautions after treatment?
On the day of injection, avoid rubbing the injection site firmly, strenuous exercise, alcohol consumption, saunas, and other activities that promote blood circulation. From the next day onward, normal daily life is possible. Daily sun protection and sunscreen use are also important for maintaining skin condition.
ZetithAIに続けて聞く →How do I make a reservation?
Reservations can be made via LINE or telephone. During consultation, we will explain in detail your current skin condition, goals, and treatment details, so please feel free to inquire.
ZetithAIに続けて聞く →Consultations about this treatment are free.
Book / free consult via LINE
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