Does Moist Shot really work? What research on hyaluronic acid and PDRN reveals

Moist Shot (a skin injection combining hyaluronic acid and PDRN) is a treatment for which research confirming the combination itself has not yet been found. Reports show that hyaluronic acid injection increases skin moisture content and luster[1], and PDRN's role in supporting skin recovery has been studied[2]. What can be expected is becoming clearer from research on each ingredient.

What can be expected from the hyaluronic acid component?

Hyaluronic acid injection mainly offers improved skin hydration and luster. A review of 12 studies showed increased skin moisture content and luster after injection[1].

However, skin elasticity and the appearance of age spots showed no marked difference[1]. If you want to significantly address firmness or age spots, it is worth comparing other treatments as well.

What does PDRN do for the skin?

PDRN is a fragmented form of DNA. Its roles in supporting skin recovery and reducing inflammation have been studied[2]. In Korea, injectable medications using PDRN have been approved and are used in dermatology[2].

A component very similar to PDRN is PN (polynucleotide). PN is made of longer DNA than PDRN, and its primary role is in improving skin foundation[2].

It has been pointed out that in published papers, the terms PDRN and PN are used interchangeably, which causes confusion[3]. Even if a product is labeled 'PDRN,' confirm what the ingredient actually is by asking for an explanation.

Is there a difference compared to hyaluronic acid injection alone?

Tests comparing hyaluronic acid alone with other treatments have been conducted using PN. Within the scope of this review, tests comparing PDRN in the same way were not found.

In a trial with 27 people receiving three injections around the eyes, one side with PN and the other with hyaluronic acid, there was no difference in the appearance improvement score[4]Skin texture and pores improved more on the PN side, with no severe side effects.[4].

This result is from PN. It does not necessarily apply directly to PDRN or Moist Shot.

Does combining them enhance the effect?

Whether combining enhances the effect is not yet clear. There is research using a formulation combining PN and hyaluronic acid around the eyes, and benefits of the combination have been reported.[5].

However, this is also specific to PN. How it works is noted to be heavily influenced by the quality of the ingredients and the method of application.[2].

What side effects can occur?

There have been no reports of severe side effects or long-lasting skin abnormalities from PDRN injection to date.[2].

Injection into shallow skin layers may show redness, swelling, and bruising.[6]Rarely, cases of nodules or infection from bacteria or fungi have been reported.[6].

In treatment injecting hyaluronic acid into facial wrinkles, there are reports of skin necrosis and blindness when the substance enters blood vessels, and caution is advised.[7].

What should I confirm before undergoing treatment?

At consultation, please ask about the following points.

Contents: Whether it is PDRN or PN, what type of hyaluronic acid[3]

Concerns: Whether dryness and luster are the main issues, or whether firmness and dark spots are also a concern[1]

Frequency: How many sessions and at what intervals[4]

Complications: How to respond if nodules or infection develop[6]

Whether Moist Shot is suitable for your skin cannot be decided from an article alone. At your consultation, have your skin concerns evaluated and confirm the differences compared to other skin injections.